BLASTX 1.4.13-Paracel [2002-12-12]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= At2g27120.f
(6465 letters)
Database: BlastDB/NCBI/blast/db/2003_02_27_02_00_4/nr
1,347,713 sequences; 431,508,457 total letters
Searching...................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_180280.1| putative DNA polymerase epsilon catalytic ... 4367 0.0
gb|AAF18240.1|AC011438_2 T23G18.11 [Arabidopsis thaliana]|g... 3542 0.0
ref|NP_006222.1| polymerase (DNA directed), epsilon [Homo s... 1657 0.0
gb|AAD44691.1| DNA polymerase epsilon catalytic subunit pro... 1656 0.0
gb|AAD44690.1| DNA polymerase epsilon catalytic subunit pro... 1656 0.0
>ref|NP_180280.1| putative DNA polymerase epsilon catalytic subunit; protein id:
At2g27120.1 [Arabidopsis
thaliana]|gi|3885342|gb|AAC77870.1| putative DNA
polymerase epsilon catalytic subunit [Arabidopsis
thaliana]|gi|25288543|pir||A84669 hypothetical protein
At2g27120 [imported] - Arabidopsis thaliana
Length = 2154
Score = 4367 bits (11326), Expect = 0.0
Identities = 2154/2154 (100%), Positives = 2154/2154 (100%)
Frame = +1
Query: 1 MSGRRCDRRLNVQKVSAADELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCV 180
MSGRRCDRRLNVQKVSAADELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCV
Sbjct: 1 MSGRRCDRRLNVQKVSAADELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCV 60
Query: 181 DLFFVTQDGSSFKTKYKFRPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLK 360
DLFFVTQDGSSFKTKYKFRPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLK
Sbjct: 61 DLFFVTQDGSSFKTKYKFRPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLK 120
Query: 361 NHLSGLQKKYLKVSFDTVQQLVEVKRDLLHIVERNLAKFNALEAYESILSGKREQRPQDC 540
NHLSGLQKKYLKVSFDTVQQLVEVKRDLLHIVERNLAKFNALEAYESILSGKREQRPQDC
Sbjct: 121 NHLSGLQKKYLKVSFDTVQQLVEVKRDLLHIVERNLAKFNALEAYESILSGKREQRPQDC 180
Query: 541 LDSVVDLREYDVPYHVRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDI 720
LDSVVDLREYDVPYHVRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDI
Sbjct: 181 LDSVVDLREYDVPYHVRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDI 240
Query: 721 ETVKLPLKFPDAEYDQIMMISYMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTN 900
ETVKLPLKFPDAEYDQIMMISYMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTN
Sbjct: 241 ETVKLPLKFPDAEYDQIMMISYMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTN 300
Query: 901 VTNEVELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQG 1080
VTNEVELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQG
Sbjct: 301 VTNEVELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQG 360
Query: 1081 ECRAKFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTM 1260
ECRAKFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTM
Sbjct: 361 ECRAKFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTM 420
Query: 1261 ASYSVSDAVATYYLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVV 1440
ASYSVSDAVATYYLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVV
Sbjct: 421 ASYSVSDAVATYYLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVV 480
Query: 1441 CPNKNQADPEKFYQGKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGR 1620
CPNKNQADPEKFYQGKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGR
Sbjct: 481 CPNKNQADPEKFYQGKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGR 540
Query: 1621 DLEYAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIIL 1800
DLEYAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIIL
Sbjct: 541 DLEYAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIIL 600
Query: 1801 TNRLQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESESVD 1980
TNRLQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESESVD
Sbjct: 601 TNRLQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESESVD 660
Query: 1981 AGANMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVREAGICMRENPFYV 2160
AGANMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVREAGICMRENPFYV
Sbjct: 661 AGANMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVREAGICMRENPFYV 720
Query: 2161 DTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNSF 2340
DTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNSF
Sbjct: 721 DTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNSF 780
Query: 2341 YGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPEN 2520
YGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPEN
Sbjct: 781 YGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPEN 840
Query: 2521 FTFKTIDMKKFTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDGPY 2700
FTFKTIDMKKFTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDGPY
Sbjct: 841 FTFKTIDMKKFTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDGPY 900
Query: 2701 KAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHGS 2880
KAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHGS
Sbjct: 901 KAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHGS 960
Query: 2881 TLEECYSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTTA 3060
TLEECYSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTTA
Sbjct: 961 TLEECYSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTTA 1020
Query: 3061 KRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKIS 3240
KRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKIS
Sbjct: 1021 KRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKIS 1080
Query: 3241 SYTGIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDKFRQGK 3420
SYTGIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDKFRQGK
Sbjct: 1081 SYTGIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDKFRQGK 1140
Query: 3421 IVDMFSSANKDHSTTQDNVVADIEEFCKENRPSVKGPKPVARSFEVDRNHSEGKQQESWD 3600
IVDMFSSANKDHSTTQDNVVADIEEFCKENRPSVKGPKPVARSFEVDRNHSEGKQQESWD
Sbjct: 1141 IVDMFSSANKDHSTTQDNVVADIEEFCKENRPSVKGPKPVARSFEVDRNHSEGKQQESWD 1200
Query: 3601 PEFHDISLQNVDKNVDYQGWLELEKRKWKMTLTNKKKRRFDDLKPCNQIDAHKINKKVCK 3780
PEFHDISLQNVDKNVDYQGWLELEKRKWKMTLTNKKKRRFDDLKPCNQIDAHKINKKVCK
Sbjct: 1201 PEFHDISLQNVDKNVDYQGWLELEKRKWKMTLTNKKKRRFDDLKPCNQIDAHKINKKVCK 1260
Query: 3781 GRVGVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVVVEGLMLKIPLTIPRVFYINS 3960
GRVGVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVVVEGLMLKIPLTIPRVFYINS
Sbjct: 1261 GRVGVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVVVEGLMLKIPLTIPRVFYINS 1320
Query: 3961 KASIAGNFTGKCINKILPHGKPCYNLMEARHLHNTHILLLVNIQEDQFIKESKKLAALLA 4140
KASIAGNFTGKCINKILPHGKPCYNLMEARHLHNTHILLLVNIQEDQFIKESKKLAALLA
Sbjct: 1321 KASIAGNFTGKCINKILPHGKPCYNLMEARHLHNTHILLLVNIQEDQFIKESKKLAALLA 1380
Query: 4141 DPEIEGIYETKMPLEFSAICQIGCVCKIEDTAKHRNTQDGWKLGELHRITTTECRYLENS 4320
DPEIEGIYETKMPLEFSAICQIGCVCKIEDTAKHRNTQDGWKLGELHRITTTECRYLENS
Sbjct: 1381 DPEIEGIYETKMPLEFSAICQIGCVCKIEDTAKHRNTQDGWKLGELHRITTTECRYLENS 1440
Query: 4321 IPLVYLYHSTSTGRAVYVLYCHASKLMSVVVVNPYGDKELLSSALERQFRDRCQELSPEP 4500
IPLVYLYHSTSTGRAVYVLYCHASKLMSVVVVNPYGDKELLSSALERQFRDRCQELSPEP
Sbjct: 1441 IPLVYLYHSTSTGRAVYVLYCHASKLMSVVVVNPYGDKELLSSALERQFRDRCQELSPEP 1500
Query: 4501 FSWDGILFQVEYVDHPEAATKFLQKALCEYREENCGATVAVIECPDFNTTKEGVKALEDF 4680
FSWDGILFQVEYVDHPEAATKFLQKALCEYREENCGATVAVIECPDFNTTKEGVKALEDF
Sbjct: 1501 FSWDGILFQVEYVDHPEAATKFLQKALCEYREENCGATVAVIECPDFNTTKEGVKALEDF 1560
Query: 4681 PCVRIPFNDDDNSYQPVSWQRPAAKIAVLRCASAIQWLDRRIAQSRYAHVPLGNFGRDWL 4860
PCVRIPFNDDDNSYQPVSWQRPAAKIAVLRCASAIQWLDRRIAQSRYAHVPLGNFGRDWL
Sbjct: 1561 PCVRIPFNDDDNSYQPVSWQRPAAKIAVLRCASAIQWLDRRIAQSRYAHVPLGNFGRDWL 1620
Query: 4861 TFTVDIFLSRALRDQQQVLWVSDNGVPDLGDINNEETFLADELQETSLLFPGAYRKVSVE 5040
TFTVDIFLSRALRDQQQVLWVSDNGVPDLGDINNEETFLADELQETSLLFPGAYRKVSVE
Sbjct: 1621 TFTVDIFLSRALRDQQQVLWVSDNGVPDLGDINNEETFLADELQETSLLFPGAYRKVSVE 1680
Query: 5041 LKVHRLAVNALLKSDLVSEMEGGGFLGVNSRGSSLNDNGSFDENNGCAQAFRVLKQLIKR 5220
LKVHRLAVNALLKSDLVSEMEGGGFLGVNSRGSSLNDNGSFDENNGCAQAFRVLKQLIKR
Sbjct: 1681 LKVHRLAVNALLKSDLVSEMEGGGFLGVNSRGSSLNDNGSFDENNGCAQAFRVLKQLIKR 1740
Query: 5221 LLHDACNSGNIYADSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGA 5400
LLHDACNSGNIYADSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGA
Sbjct: 1741 LLHDACNSGNIYADSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGA 1800
Query: 5401 IIIYADFSKVIIDTGKFDLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHN 5580
IIIYADFSKVIIDTGKFDLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHN
Sbjct: 1801 IIIYADFSKVIIDTGKFDLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHN 1860
Query: 5581 YAGIRATGDEISGNEVTIEPKWSVARHLPEYIQKDFIIIVATFIFGPWKFALEKKRGSAE 5760
YAGIRATGDEISGNEVTIEPKWSVARHLPEYIQKDFIIIVATFIFGPWKFALEKKRGSAE
Sbjct: 1861 YAGIRATGDEISGNEVTIEPKWSVARHLPEYIQKDFIIIVATFIFGPWKFALEKKRGSAE 1920
Query: 5761 SLEAEMVEYLKEQIGTRFISMIVEKIGNIRSHIKDINVSDASWASGQAPKGDYTFEFIQI 5940
SLEAEMVEYLKEQIGTRFISMIVEKIGNIRSHIKDINVSDASWASGQAPKGDYTFEFIQI
Sbjct: 1921 SLEAEMVEYLKEQIGTRFISMIVEKIGNIRSHIKDINVSDASWASGQAPKGDYTFEFIQI 1980
Query: 5941 ITAVLALDQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGAYRDL 6120
ITAVLALDQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGAYRDL
Sbjct: 1981 ITAVLALDQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGAYRDL 2040
Query: 6121 DFCRDSALLTEKEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCNQVKA 6300
DFCRDSALLTEKEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCNQVKA
Sbjct: 2041 DFCRDSALLTEKEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCNQVKA 2100
Query: 6301 AHLTEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWILFATSC 6462
AHLTEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWILFATSC
Sbjct: 2101 AHLTEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWILFATSC 2154
>gb|AAF18240.1|AC011438_2 T23G18.11 [Arabidopsis thaliana]|gi|15223158|ref|NP_172303.1| DNA
polymerase epsilon catalytic subunit, putative; protein
id: At1g08260.1 [Arabidopsis thaliana]
Length = 2271
Score = 3542 bits (9184), Expect = 0.0
Identities = 1801/2277 (79%), Positives = 1934/2277 (84%), Gaps = 139/2277 (6%)
Frame = +1
Query: 46 SAADELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCVDLFFVTQDGSSFKTK 225
+A DELE+KLGFGLFS+GETRLGWLLTF+SSSWED DTGK +SCVDL+FVTQDG SFKTK
Sbjct: 24 TAEDELESKLGFGLFSEGETRLGWLLTFSSSSWEDRDTGKVYSCVDLYFVTQDGFSFKTK 83
Query: 226 YKFRPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLKNHLSGLQKKYLKVSF 405
YKFRPY YAATKD MELE+EAYLRRRYERQVADI+IV KEDL LKNHLSGLQKKYLK+SF
Sbjct: 84 YKFRPYFYAATKDKMELELEAYLRRRYERQVADIEIVEKEDLDLKNHLSGLQKKYLKISF 143
Query: 406 DTVQQLVEVKRDLLHIVERNLAKFNALEAYESILSGKREQRPQDCLDSVVDLREYDVPYH 585
DTVQQL+EVKRDLLHIVERN AKF+ALEAYESIL+GKREQRPQDCLDS+VDLREYDVPYH
Sbjct: 144 DTVQQLMEVKRDLLHIVERNQAKFDALEAYESILAGKREQRPQDCLDSIVDLREYDVPYH 203
Query: 586 VRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDIETVKLPLKFPDAEYD 765
VRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDIET KLPLKFPDAEYD
Sbjct: 204 VRFAIDNDVRSGQWYNVSISSTDVILEKRTDLLQRAEVRVCAFDIETTKLPLKFPDAEYD 263
Query: 766 QIMMISYMVDGQGFLITNRE---CVGKDIEDLEYTPKPEFEGYFKVTNVTNEVELLRKWF 936
QIMMISYMVDGQGFLI NRE CVG+D+EDLEYTPKPEFEGYFKVTNV NEVELL++WF
Sbjct: 264 QIMMISYMVDGQGFLIINREVTACVGEDVEDLEYTPKPEFEGYFKVTNVKNEVELLQRWF 323
Query: 937 SHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRAKFVCHLDC 1116
HMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRAKF CHLDC
Sbjct: 324 YHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRAKFACHLDC 383
Query: 1117 FSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTMASYSVSDAVATY 1296
F+WVKRDSYLPQGS GLKAVTK KLGYDPLEVNPEDMVRFAMEKPQTMASYSVSDAVATY
Sbjct: 384 FAWVKRDSYLPQGSHGLKAVTKAKLGYDPLEVNPEDMVRFAMEKPQTMASYSVSDAVATY 443
Query: 1297 YLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVE---------AYKANVVCPN 1449
YLYMTYV+PF+FSLATIIPMVPDEVLRKGSGTLCEMLLMVE AYKANVVCPN
Sbjct: 444 YLYMTYVNPFIFSLATIIPMVPDEVLRKGSGTLCEMLLMVEVSTYLPQAQAYKANVVCPN 503
Query: 1450 KNQADPEKFYQGKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGRDLE 1629
KNQADPEKFYQ +LLESETYIGGHVECL+SG QLIDNLGRDLE
Sbjct: 504 KNQADPEKFYQNQLLESETYIGGHVECLESG------------------QLIDNLGRDLE 545
Query: 1630 YAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNR 1809
YAITVEGKMRMDS+SN+DEVK+ I+EKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNR
Sbjct: 546 YAITVEGKMRMDSISNYDEVKDEIKEKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNR 605
Query: 1810 LQ-----PPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESES 1974
LQ PPSIVTDE+CTACDFN P KTCLRKLEWVWRGVTF G KS+YYHLKKQIESE
Sbjct: 606 LQVHLISPPSIVTDEICTACDFNRPGKTCLRKLEWVWRGVTFMGKKSDYYHLKKQIESEF 665
Query: 1975 VDAGANMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVREAGICMRENPF 2154
VDAGAN+ SSK FLDLPKV+QQSKLKERLKKYCQKAY RVLDKPITEVREAGICMRENPF
Sbjct: 666 VDAGANIMSSKSFLDLPKVDQQSKLKERLKKYCQKAYKRVLDKPITEVREAGICMRENPF 725
Query: 2155 YVDTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILN 2334
YVDTVRSFRDRRYEYKTLNKVWKGKLSEAKASGN IKIQEA DMVVVYDSLQLAHKCILN
Sbjct: 726 YVDTVRSFRDRRYEYKTLNKVWKGKLSEAKASGNSIKIQEAQDMVVVYDSLQLAHKCILN 785
Query: 2335 SFYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFP 2514
SFYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWC LPGSFP
Sbjct: 786 SFYGYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCCLPGSFP 845
Query: 2515 ENFTFKTIDMKKFTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDG 2694
ENFTFKTIDMKK TISYPCV+LNVDVAKNN+NDQYQTLVDPVRKTY S SECSIEFEVDG
Sbjct: 846 ENFTFKTIDMKKLTISYPCVMLNVDVAKNNTNDQYQTLVDPVRKTYKSHSECSIEFEVDG 905
Query: 2695 PYKAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLH 2874
PYKAMIIPASKEEGILIKKRYAVFNHDGT+AELKGFE+KRRGELKLIKVFQAELFDKFLH
Sbjct: 906 PYKAMIIPASKEEGILIKKRYAVFNHDGTLAELKGFEIKRRGELKLIKVFQAELFDKFLH 965
Query: 2875 GSTLEECYSAVAAVANRWLDL----------------------LEGQGKDIADSELLDYI 2988
GSTLEECYSAVAAVA+RWLDL L+ QGKDIADSELLDYI
Sbjct: 966 GSTLEECYSAVAAVADRWLDLLDVCEISCFFWVIYLIGFLSHFLQNQGKDIADSELLDYI 1025
Query: 2989 SESSTMSKSLADYGQQKSCAVTTAKRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERA 3168
SESSTMSKSLADYG+QKSCAVTTAKRLA+FLG TMVKDKGLRCQYIVA EP+GTPVSERA
Sbjct: 1026 SESSTMSKSLADYGEQKSCAVTTAKRLAEFLGVTMVKDKGLRCQYIVACEPKGTPVSERA 1085
Query: 3169 VPVAIFQTDDPEKKFYLQKWCKISSYTGIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVA 3348
VPVAIF T+ KF+L+KWCK SS GIR IIDW YYKQRL SAIQKVITIPAAMQKVA
Sbjct: 1086 VPVAIFTTNPEVMKFHLRKWCKTSSDVGIRLIIDWSYYKQRLSSAIQKVITIPAAMQKVA 1145
Query: 3349 NPVLRVRHPYWLEKKV---CDKFRQGKIVDMFSSANK------DHSTTQDNVVADIEEFC 3501
NPV RV HP WL KKV DKFRQ K+VDMFSSANK D T+DN V DIE+FC
Sbjct: 1146 NPVPRVLHPDWLHKKVREKDDKFRQRKLVDMFSSANKDVVLDTDLPVTKDN-VEDIEDFC 1204
Query: 3502 KENRPSVKGPKPVARSFEVDRNHSEGKQQESWDPEFHDISLQNVDKNVDYQGWLELEKRK 3681
KENRPSVKGPKP+ARS+EV++ SE +QQESWD EFHDIS QN+DK+V+YQGWLEL+KRK
Sbjct: 1205 KENRPSVKGPKPIARSYEVNKKQSECEQQESWDTEFHDISFQNIDKSVNYQGWLELKKRK 1264
Query: 3682 WKMTLTNKKKRRFDDLKPCNQIDAHKINKKVCKGRVGVGSYFRRPEEALTSSYLQ---II 3852
WK+TL KKKRR DL+ NQ+D H+IN+KV +GR GVGSYFRRPEEALTSS+ Q II
Sbjct: 1265 WKVTLEKKKKRRLGDLRSSNQVDTHEINQKVGQGRGGVGSYFRRPEEALTSSHWQVCTII 1324
Query: 3853 QLVQSPQSGQFFAWVVVEGLMLKIPLTIPRVFYINSKASIAGNFTGKCINKILPHGKPCY 4032
QLV SPQSGQFFAWVVVEGLMLKIPL+IPRVFYINSK I F GKC+NKILPHG+PCY
Sbjct: 1325 QLVPSPQSGQFFAWVVVEGLMLKIPLSIPRVFYINSKVPIDEYFQGKCVNKILPHGRPCY 1384
Query: 4033 NLMEARHLHNTHILLLVNIQEDQFIKESKKLAALLADPEIEGIYETKMPLEFSAICQIGC 4212
+L EA V IQEDQF KESKK AALLADP +EGIYETK+PLEFSAICQIGC
Sbjct: 1385 SLTEA----------CVKIQEDQFKKESKKRAALLADPGVEGIYETKVPLEFSAICQIGC 1434
Query: 4213 VCKIEDTAKHRNTQDGWKLGELHRITTTECRYLENSIPLVYLYHSTSTGRAVYVLYCHAS 4392
VCKI++ AKHRNTQDGW++GELH TTTEC YL+ SIPLVYLY+STSTGRA+YVLYCH S
Sbjct: 1435 VCKIDNKAKHRNTQDGWEVGELHMKTTTECHYLKRSIPLVYLYNSTSTGRAIYVLYCHVS 1494
Query: 4393 KLMSVVVVNPYGDKELLSSALERQFRDRCQELSPEPFSWDGILFQVEYVDHPEAATKFLQ 4572
KLMS VVV+P+ ELL SALERQFRD C ELS + SWDGI FQV YVDHPEAA K +Q
Sbjct: 1495 KLMSAVVVDPFNGNELLPSALERQFRDSCLELSLDSLSWDGIRFQVHYVDHPEAAKKIIQ 1554
Query: 4573 KALCEYREENCGATVAVIECPDFNTTKEGVKALEDFPCVRIPFNDDDNSYQPVSWQRPAA 4752
+A+ EYREENCG TVAVIECPDF KEG+KAL+DFPCVRIPFNDDDNSYQPVSWQRPAA
Sbjct: 1555 RAISEYREENCGPTVAVIECPDFTFMKEGIKALDDFPCVRIPFNDDDNSYQPVSWQRPAA 1614
Query: 4753 KIAVLRCASAIQWLDRRIAQSRYAHVPLGNFGRDWLTFTVDIFLSRALRDQQQVLWVSDN 4932
KIA+ RCA+A QWLDRRI QSRYAHVPLGNFG DWLTFT+DIFLSRALRDQQQVLWVSDN
Sbjct: 1615 KIAMFRCAAAFQWLDRRITQSRYAHVPLGNFGLDWLTFTIDIFLSRALRDQQQVLWVSDN 1674
Query: 4933 GVPDLGDINNEETFLADELQETSLLFPGAYRKVSVELKVHRLAVNALLKSDLVSEMEGGG 5112
GVPDLG INNEE F ADE+Q+TSL+FPGAYRKVSVELK+H LAVNALLKS+LV+EMEGGG
Sbjct: 1675 GVPDLGGINNEEAFFADEVQQTSLVFPGAYRKVSVELKIHNLAVNALLKSNLVNEMEGGG 1734
Query: 5113 FLG----VNSRGSSLNDNGSFDENNGCAQAFRVLKQLIKRLLHDACNSGNIYADSILQHL 5280
F+G VN RG + NDN SFDE GCAQAFRVLKQLI L D S NIYADSILQ L
Sbjct: 1735 FMGFEQDVNPRGINSNDNTSFDETTGCAQAFRVLKQLIHSCLTDVRKSKNIYADSILQRL 1794
Query: 5281 SWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIIDTGKFDLS 5460
SWWL SPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIIDT KFDLS
Sbjct: 1795 SWWLCSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIIDTVKFDLS 1854
Query: 5461 AAKTYCESLLTVMGSRDIFKLILLE----PVHYWHSLLFMD------QHNYAGIRATGDE 5610
AAK YCESLL+ + +R + L+ + H HS D +NYAGIRA DE
Sbjct: 1855 AAKAYCESLLSTVRNRLVSSLLDIHVYDLKSHGLHSFSCHDFCASPLTYNYAGIRA-DDE 1913
Query: 5611 ISGNEVTIEPKWSVARHLPEYI-------------------------------------- 5676
IS +EVTIEPKWSVARHLPEYI
Sbjct: 1914 ISLDEVTIEPKWSVARHLPEYIEVWRQNPHSNQCSFSENKKHVATHGPFFLDTDAFHLSW 1973
Query: 5677 QKDFIIIVATFIFGPWKFALEKKRGSAESLEAEMVEYLKEQIGTRFISMIVEKIGNIRSH 5856
Q+DFIII+A FIF PWKFA+E K+GS+ESLEA+M+EYL+EQIG+ FI+M+V+K+ +I SH
Sbjct: 1974 QRDFIIIIAKFIFDPWKFAIENKKGSSESLEAQMIEYLREQIGSTFINMLVKKVDDIMSH 2033
Query: 5857 IKDINVSDASWASGQAPKGDYTFEFIQIITAVLALDQNVQQDVL---------------- 5988
+K+INVSDAS SGQAPKGDY+ EFIQ+I+AVLALDQNVQQDVL
Sbjct: 2034 MKEINVSDASRVSGQAPKGDYSLEFIQVISAVLALDQNVQQDVLLKTLFITDFIHKSNLI 2093
Query: 5989 --------------------VMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGA 6108
VMRK LLKYIKVKECAAEAEF+DPGPSFILPNVACSNC A
Sbjct: 2094 SGNVVLETMFTNRAGFFFEWVMRKSLLKYIKVKECAAEAEFLDPGPSFILPNVACSNCDA 2153
Query: 6109 YRDLDFCRDSALLTEKEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCN 6288
YRDLD CRD ALLTEKEWSCAD QC KIYD+EQ+ESS+++MVRQRERMY +QD+VC RCN
Sbjct: 2154 YRDLDICRDPALLTEKEWSCADTQCGKIYDREQMESSLLEMVRQRERMYHMQDVVCIRCN 2213
Query: 6289 QVKAAHLTEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWILFATS 6459
QVKAAHLTEQCECSGSFRCKESGS+F KR+EIF+DIAKRQKFRLLEE ISWI++ S
Sbjct: 2214 QVKAAHLTEQCECSGSFRCKESGSEFSKRMEIFMDIAKRQKFRLLEEYISWIIYGPS 2270
>ref|NP_006222.1| polymerase (DNA directed), epsilon [Homo
sapiens]|gi|12644390|sp|Q07864|DPOE_HUMAN DNA polymerase
epsilon, catalytic subunit A (DNA polymerase II subunit
A)|gi|3192938|gb|AAC19148.1| DNA polymerase epsilon,
catalytic polypeptide [Homo sapiens]
Length = 2286
Score = 1657 bits (4290), Expect = 0.0
Identities = 934/2266 (41%), Positives = 1344/2266 (59%), Gaps = 135/2266 (5%)
Frame = +1
Query: 55 DELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCVDLFFVTQDGSSFKTKYKF 234
D+++ + GF + + GWL+ + D D + S VD +F+ DGS FK +
Sbjct: 42 DKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDK-RLGSAVDYYFIQDDGSRFKVALPY 100
Query: 235 RPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLKNHLSGLQKKYLKVSFDTV 414
+PY Y AT+ E EV ++L ++++ ++A ++ V KEDL L NHL GL++ Y+++SF TV
Sbjct: 101 KPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTV 160
Query: 415 QQLVEVKRDLLHIVERNLAKFNALEAYESILSG------------KREQRPQDCLDSVVD 558
+ LV+V++++ V++N + +A +AY ++LS + ++ D LD++VD
Sbjct: 161 EDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVD 220
Query: 559 LREYDVPYHVRFAIDNDVRSGQWYNVSI--SSTDVILEKRTDLLQRAEVRVCAFDIETVK 732
+REYDVPYH+R +ID + WYNV ++ V + +R DL++R + V AFDIET K
Sbjct: 221 MREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTK 280
Query: 733 LPLKFPDAEYDQIMMISYMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTNVTNE 912
LPLKFPDAE DQIMMISYM+DGQG+LITNRE V +DIED E+TPKPE+EG F V N +E
Sbjct: 281 LPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDE 340
Query: 913 VELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRA 1092
L+++WF H+QE KP I VTYNGDFFDWPF+E RA+ HG+ M +E+GF+ D +QGE +A
Sbjct: 341 AHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKD-SQGEYKA 399
Query: 1093 KFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTMASYS 1272
H+DC WVKRDSYLP GS LKA K KLGYDP+E++PEDM R A E+PQT+A+YS
Sbjct: 400 PQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYS 459
Query: 1273 VSDAVATYYLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVVCPNK 1452
VSDAVATYYLYM YVHPF+F+L TIIPM PDEVLRKGSGTLCE LLMV+A+ AN++ PNK
Sbjct: 460 VSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNK 519
Query: 1453 NQADPEKFYQ-GKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGRDLE 1629
+ + K G +L+SETY+GGHVE L+SGVFRSDIP F+++ +A+ L+ + + L
Sbjct: 520 QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLR 579
Query: 1630 YAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNR 1809
+A+ E K+ ++ V+NF+EV + I+ KL L+D P R E PLIYHLDV AMYPNIILTNR
Sbjct: 580 HALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNR 639
Query: 1810 LQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESESVDAGA 1989
LQP ++V + C ACDFN P C RK+ W WRG ++SEY+ ++ Q+ESE
Sbjct: 640 LQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLF 699
Query: 1990 NMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVRE--AGICMRENPFYVD 2163
++ F +L + EQ K RL YC+KAY ++ IT+V E IC REN FYVD
Sbjct: 700 PEGPARAFHELSREEQAKYEKRRLADYCRKAYKKI---HITKVEERLTTICQRENSFYVD 756
Query: 2164 TVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNSFY 2343
TVR+FRDRRYE+K L+KVWK KLS A G+ +++ +M V+YDSLQLAHKCILNSFY
Sbjct: 757 TVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFY 816
Query: 2344 GYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPENF 2523
GYVMRKGARWYSMEMAG+V +TGA II AR LIE+IG+PLELDTDGIWC LP SFPENF
Sbjct: 817 GYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENF 876
Query: 2524 TFKTIDMKK--FTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDGP 2697
FKT ++KK TISYP +LN+ V + +NDQYQ L +P TY +RSE SI FEVDGP
Sbjct: 877 VFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGP 936
Query: 2698 YKAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHG 2877
Y AMI+PASKEEG +KKRYAVFN DG++AELKGFE+KRRGEL+LIK+FQ+ +F+ FL G
Sbjct: 937 YLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKG 996
Query: 2878 STLEECYSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTT 3057
STLEE Y +VA VA+ WLD+L + ++ DSEL + ISE+ +MS+ L DYG+QKS +++T
Sbjct: 997 STLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSIST 1056
Query: 3058 AKRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKI 3237
AKRLA+FLGD MVKD GL C+YI++R+PEG+PV+ERA+P+AIFQ + +K +L+KW K
Sbjct: 1057 AKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKS 1116
Query: 3238 SSYT--GIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDK-- 3405
SS IR+I+DW YY +RL SAIQK+ITIPAA+Q+V NPV RV+HP WL KK+ +K
Sbjct: 1117 SSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKND 1176
Query: 3406 -FRQGKIVDMFSSANKDHST----TQDN---VVADIEEFCKENRPSVKGPKPVARSFEVD 3561
++Q KI ++F+ + T ++D+ D+E+F P P V R +
Sbjct: 1177 VYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLW 1236
Query: 3562 RNHSEGKQQESWDPEFHDISLQNV---DKNVDYQGWLELEKRKWKM----TLTNKKKRRF 3720
+ E + P + +I Q ++ WL K+KW++ L +K++R
Sbjct: 1237 ESQEESQDLTPTVP-WQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRL 1295
Query: 3721 DDLKPCNQIDAHKINKKVCKGRVGVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVV 3900
+ + + A + G+GS+ RR ++ QI+Q+ ++ Q+G F W +
Sbjct: 1296 ESAEGVLRPGAIRDGP-----ATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWAL 1350
Query: 3901 VEGLMLKIPLTIPRVFYINSKASIAGNFTG-KCINKILPHGKPCYNLMEARHLHNTHILL 4077
V + I L+IPRVFY+N + + A + +N++LP YNL E
Sbjct: 1351 VGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYE----------- 1399
Query: 4078 LVNIQEDQFIKESKKLAALLADPEIEGIYETKMPLEFSAICQIGCVCKI-EDTAKHRNTQ 4254
++ ED + + ++ A L+ P+IEG+YET++PL F A+ +GCVC + + +H +
Sbjct: 1400 -YSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLS-- 1456
Query: 4255 DGWK-----LGELHRITTTECRYLE-NSIPLVYLYHSTSTGRAVYVLYCHASKLMSVVVV 4416
GW+ L L + + YLE SI +YLYH +A++ ++ + + SV V+
Sbjct: 1457 -GWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVL 1515
Query: 4417 NPYGDKEL--LSSALERQFRDRCQELSPEPFSWDGILFQVEYVDHPEAATKFLQKALCEY 4590
+ ++ L + + +++ PE F+V + + +Q+ L Y
Sbjct: 1516 DTVRSNQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAY 1575
Query: 4591 REENCGAT-VAVIECPDFNTTKEGVKALEDFPCVRIPFNDDDNSYQPVSWQRPAAKIAVL 4767
+EE G T +AV + + LE+FP V I D N Y + WQR A+ +
Sbjct: 1576 KEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKIN-YGVLDWQRHGARRMIR 1634
Query: 4768 RCASAIQWLDRRIAQSRYAHVPLGNFGRDWLTFTVDIFLSRALRDQQQVLWVSDNGVPDL 4947
+ L + SRY H+P+GN D TF D+F +R L+ +LW+S PDL
Sbjct: 1635 HYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDL 1694
Query: 4948 GDINNEETFLADELQETSLL---FPGAYRKVSVELKVHRLAVNALLKSDLVSEMEGGGFL 5118
G ++ L E + + + G Y V VEL + LAVN +L+S V++MEG +
Sbjct: 1695 GGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSM 1754
Query: 5119 GVN-------------SRGSSLNDNGSFDENNGCAQAFRVLKQLIKRLLHDACNSGNIYA 5259
G++ + G + + S+DE C+ FR+LK ++ + + NIYA
Sbjct: 1755 GISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYA 1814
Query: 5260 DSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIID 5439
D+ + H WLRSPSS LHDPALH LH +M+K+F L+ + +RLG+ +IYA+F+++I+
Sbjct: 1815 DNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILC 1874
Query: 5440 TGKFDLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHNYAGIRATGD---- 5607
T K + A Y E + + + S++ F + + W LL+MD NY GI+
Sbjct: 1875 TKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIH 1934
Query: 5608 ---------------------------------EISGNEVTIEPKWSVARHLPE--YIQK 5682
E S E +E W++ + LP+ Q
Sbjct: 1935 CGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQN 1994
Query: 5683 DFIIIVATFIF-------------GPWKFALEKKRGSAESLEAE--------MVEYLKEQ 5799
F++IV+ +I P + ++ S S EAE M+ + ++
Sbjct: 1995 YFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDY 2054
Query: 5800 IGTRFISMIVEKIGNIRSHIKDINVSDASWASGQAPKGDY------TFEFIQIITAVLAL 5961
+ I+ + S G + EFI+ + VL+L
Sbjct: 2055 VANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSL 2114
Query: 5962 DQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGAYRDLDFCRDSA 6141
D N+ V + + LL+ + V E + EA+F DP S++LP V C +C RDLD C+DS+
Sbjct: 2115 DTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSS 2174
Query: 6142 LLTE----KEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCNQVKAAHL 6309
+ +W C++ C YD IE +++++++++ + LQDLVC +C VK +
Sbjct: 2175 FSEDGAVLPQWLCSN--CQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSM 2232
Query: 6310 TEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWIL 6447
C C+G F F ++I IF +IA+ L E + W+L
Sbjct: 2233 PVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLL 2278
>gb|AAD44691.1| DNA polymerase epsilon catalytic subunit protein isoform b [Homo
sapiens]
Length = 2286
Score = 1656 bits (4288), Expect = 0.0
Identities = 934/2266 (41%), Positives = 1344/2266 (59%), Gaps = 135/2266 (5%)
Frame = +1
Query: 55 DELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCVDLFFVTQDGSSFKTKYKF 234
D+++ + GF + + GWL+ + D D + S VD +F+ DGS FK +
Sbjct: 42 DKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDK-RLGSAVDYYFIQDDGSRFKVALPY 100
Query: 235 RPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLKNHLSGLQKKYLKVSFDTV 414
+PY Y AT+ E EV ++L ++++ ++A ++ V KEDL L NHL GL++ Y+++SF TV
Sbjct: 101 KPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTV 160
Query: 415 QQLVEVKRDLLHIVERNLAKFNALEAYESILSG------------KREQRPQDCLDSVVD 558
+ LV+V++++ V++N + +A +AY ++LS + ++ D LD++VD
Sbjct: 161 EDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVD 220
Query: 559 LREYDVPYHVRFAIDNDVRSGQWYNVSI--SSTDVILEKRTDLLQRAEVRVCAFDIETVK 732
+REYDVPYH+R +ID + WYNV ++ V + +R DL++R + V AFDIET K
Sbjct: 221 MREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTK 280
Query: 733 LPLKFPDAEYDQIMMISYMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTNVTNE 912
LPLKFPDAE DQIMMISYM+DGQG+LITNRE V +DIED E+TPKPE+EG F V N +E
Sbjct: 281 LPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDE 340
Query: 913 VELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRA 1092
L+++WF H+QE KP I VTYNGDFFDWPF+E RA+ HG+ M +E+GF+ D +QGE +A
Sbjct: 341 AHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKD-SQGEYKA 399
Query: 1093 KFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTMASYS 1272
H+DC WVKRDSYLP GS LKA K KLGYDP+E++PEDM R A E+PQT+A+YS
Sbjct: 400 PQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYS 459
Query: 1273 VSDAVATYYLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVVCPNK 1452
VSDAVATYYLYM YVHPF+F+L TIIPM PDEVLRKGSGTLCE LLMV+A+ AN++ PNK
Sbjct: 460 VSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNK 519
Query: 1453 NQADPEKFYQ-GKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGRDLE 1629
+ + K G +L+SETY+GGHVE L+SGVFRSDIP F+++ +A+ L+ + + L
Sbjct: 520 QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLR 579
Query: 1630 YAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNR 1809
+A+ E K+ ++ V+NF+EV + I+ KL L+D P R E PLIYHLDV AMYPNIILTNR
Sbjct: 580 HALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNR 639
Query: 1810 LQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESESVDAGA 1989
LQP ++V + C ACDFN P C RK+ W WRG ++SEY+ ++ Q+ESE
Sbjct: 640 LQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLF 699
Query: 1990 NMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVRE--AGICMRENPFYVD 2163
++ F +L + EQ K RL YC+KAY ++ IT+V E IC REN FYVD
Sbjct: 700 PEGPARAFHELSREEQAKYEKRRLADYCRKAYKKI---HITKVEERLTTICQRENSFYVD 756
Query: 2164 TVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNSFY 2343
TVR+FRDRRYE+K L+KVWK KLS A G+ +++ +M V+YDSLQLAHKCILNSFY
Sbjct: 757 TVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFY 816
Query: 2344 GYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPENF 2523
GYVMRKGARWYSMEMAG+V +TGA II AR LIE+IG+PLELDTDGIWC LP SFPENF
Sbjct: 817 GYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENF 876
Query: 2524 TFKTIDMKK--FTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDGP 2697
FKT ++KK TISYP +LN+ V + +NDQYQ L +P TY +RSE SI FEVDGP
Sbjct: 877 VFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGP 936
Query: 2698 YKAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHG 2877
Y AMI+PASKEEG +KKRYAVFN DG++AELKGFE+KRRGEL+LIK+FQ+ +F+ FL G
Sbjct: 937 YLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKG 996
Query: 2878 STLEECYSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTT 3057
STLEE Y +VA VA+ WLD+L + ++ DSEL + ISE+ +MS+ L DYG+QKS +++T
Sbjct: 997 STLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSIST 1056
Query: 3058 AKRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKI 3237
AKRLA+FLGD MVKD GL C+YI++R+PEG+PV+ERA+P+AIFQ + +K +L+KW K
Sbjct: 1057 AKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKS 1116
Query: 3238 SSYT--GIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDK-- 3405
SS IR+I+DW YY +RL SAIQK+ITIPAA+Q+V NPV RV+HP WL KK+ +K
Sbjct: 1117 SSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKND 1176
Query: 3406 -FRQGKIVDMFSSANKDHST----TQDN---VVADIEEFCKENRPSVKGPKPVARSFEVD 3561
++Q KI ++F+ + T ++D+ D+E+F P P V R +
Sbjct: 1177 VYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLW 1236
Query: 3562 RNHSEGKQQESWDPEFHDISLQNV---DKNVDYQGWLELEKRKWKM----TLTNKKKRRF 3720
+ E + P + +I Q ++ WL K+KW++ L +K++R
Sbjct: 1237 ESQEESQDLTPTVP-WQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRL 1295
Query: 3721 DDLKPCNQIDAHKINKKVCKGRVGVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVV 3900
+ + + A + G+GS+ RR ++ QI+Q+ ++ Q+G F W +
Sbjct: 1296 ESAEGVLRPGAIRDGP-----ATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWAL 1350
Query: 3901 VEGLMLKIPLTIPRVFYINSKASIAGNFTG-KCINKILPHGKPCYNLMEARHLHNTHILL 4077
V + I L+IPRVFY+N + + A + +N++LP YNL E
Sbjct: 1351 VGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYE----------- 1399
Query: 4078 LVNIQEDQFIKESKKLAALLADPEIEGIYETKMPLEFSAICQIGCVCKI-EDTAKHRNTQ 4254
++ ED + + ++ A L+ P+IEG+YET++PL F A+ +GCVC + + +H +
Sbjct: 1400 -YSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLS-- 1456
Query: 4255 DGWK-----LGELHRITTTECRYLE-NSIPLVYLYHSTSTGRAVYVLYCHASKLMSVVVV 4416
GW+ L L + + YLE SI +YLYH +A++ ++ + + SV V+
Sbjct: 1457 -GWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVL 1515
Query: 4417 NPYGDKEL--LSSALERQFRDRCQELSPEPFSWDGILFQVEYVDHPEAATKFLQKALCEY 4590
+ ++ L + + +++ PE F+V + + +Q+ L Y
Sbjct: 1516 DTVRTDQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAY 1575
Query: 4591 REENCGAT-VAVIECPDFNTTKEGVKALEDFPCVRIPFNDDDNSYQPVSWQRPAAKIAVL 4767
+EE G T +AV + + LE+FP V I D N Y + WQR A+ +
Sbjct: 1576 KEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKIN-YGVLDWQRHGARRMIR 1634
Query: 4768 RCASAIQWLDRRIAQSRYAHVPLGNFGRDWLTFTVDIFLSRALRDQQQVLWVSDNGVPDL 4947
+ L + SRY H+P+GN D TF D+F +R L+ +LW+S PDL
Sbjct: 1635 HYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDL 1694
Query: 4948 GDINNEETFLADELQETSLL---FPGAYRKVSVELKVHRLAVNALLKSDLVSEMEGGGFL 5118
G ++ L E + + + G Y V VEL + LAVN +L+S V++MEG +
Sbjct: 1695 GGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSM 1754
Query: 5119 GVN-------------SRGSSLNDNGSFDENNGCAQAFRVLKQLIKRLLHDACNSGNIYA 5259
G++ + G + + S+DE C+ FR+LK ++ + + NIYA
Sbjct: 1755 GISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYA 1814
Query: 5260 DSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIID 5439
D+ + H WLRSPSS LHDPALH LH +M+K+F L+ + +RLG+ +IYA+F+++I+
Sbjct: 1815 DNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILC 1874
Query: 5440 TGKFDLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHNYAGIRATGD---- 5607
T K + A Y E + + + S++ F + + W LL+MD NY GI+
Sbjct: 1875 TKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIH 1934
Query: 5608 ---------------------------------EISGNEVTIEPKWSVARHLPE--YIQK 5682
E S E +E W++ + LP+ Q
Sbjct: 1935 CGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQN 1994
Query: 5683 DFIIIVATFIF-------------GPWKFALEKKRGSAESLEAE--------MVEYLKEQ 5799
F++IV+ +I P + ++ S S EAE M+ + ++
Sbjct: 1995 YFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDY 2054
Query: 5800 IGTRFISMIVEKIGNIRSHIKDINVSDASWASGQAPKGDY------TFEFIQIITAVLAL 5961
+ I+ + S G + EFI+ + VL+L
Sbjct: 2055 VANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSL 2114
Query: 5962 DQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGAYRDLDFCRDSA 6141
D N+ V + + LL+ + V E + EA+F DP S++LP V C +C RDLD C+DS+
Sbjct: 2115 DTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSS 2174
Query: 6142 LLTE----KEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCNQVKAAHL 6309
+ +W C++ C YD IE +++++++++ + LQDLVC +C VK +
Sbjct: 2175 FSEDGAVLPQWLCSN--CQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSM 2232
Query: 6310 TEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWIL 6447
C C+G F F ++I IF +IA+ L E + W+L
Sbjct: 2233 PVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLL 2278
>gb|AAD44690.1| DNA polymerase epsilon catalytic subunit protein isoform a [Homo
sapiens]
Length = 2297
Score = 1656 bits (4288), Expect = 0.0
Identities = 934/2266 (41%), Positives = 1344/2266 (59%), Gaps = 135/2266 (5%)
Frame = +1
Query: 55 DELETKLGFGLFSQGETRLGWLLTFASSSWEDADTGKTFSCVDLFFVTQDGSSFKTKYKF 234
D+++ + GF + + GWL+ + D D + S VD +F+ DGS FK +
Sbjct: 53 DKMDLRFGFERLKEPGEKTGWLINMHPTEILDEDK-RLGSAVDYYFIQDDGSRFKVALPY 111
Query: 235 RPYLYAATKDNMELEVEAYLRRRYERQVADIQIVHKEDLYLKNHLSGLQKKYLKVSFDTV 414
+PY Y AT+ E EV ++L ++++ ++A ++ V KEDL L NHL GL++ Y+++SF TV
Sbjct: 112 KPYFYIATRKGCEREVSSFLSKKFQGKIAKVETVPKEDLDLPNHLVGLKRNYIRLSFHTV 171
Query: 415 QQLVEVKRDLLHIVERNLAKFNALEAYESILSG------------KREQRPQDCLDSVVD 558
+ LV+V++++ V++N + +A +AY ++LS + ++ D LD++VD
Sbjct: 172 EDLVKVRKEISPAVKKNREQDHASDAYTALLSSVLQRGGVITDEEETSKKIADQLDNIVD 231
Query: 559 LREYDVPYHVRFAIDNDVRSGQWYNVSI--SSTDVILEKRTDLLQRAEVRVCAFDIETVK 732
+REYDVPYH+R +ID + WYNV ++ V + +R DL++R + V AFDIET K
Sbjct: 232 MREYDVPYHIRLSIDLKIHVAHWYNVRYRGNAFPVEITRRDDLVERPDPVVLAFDIETTK 291
Query: 733 LPLKFPDAEYDQIMMISYMVDGQGFLITNRECVGKDIEDLEYTPKPEFEGYFKVTNVTNE 912
LPLKFPDAE DQIMMISYM+DGQG+LITNRE V +DIED E+TPKPE+EG F V N +E
Sbjct: 292 LPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFEFTPKPEYEGPFCVFNEPDE 351
Query: 913 VELLRKWFSHMQELKPGIYVTYNGDFFDWPFIERRASHHGIKMNEELGFRCDQNQGECRA 1092
L+++WF H+QE KP I VTYNGDFFDWPF+E RA+ HG+ M +E+GF+ D +QGE +A
Sbjct: 352 AHLIQRWFEHVQETKPTIMVTYNGDFFDWPFVEARAAVHGLSMQQEIGFQKD-SQGEYKA 410
Query: 1093 KFVCHLDCFSWVKRDSYLPQGSQGLKAVTKVKLGYDPLEVNPEDMVRFAMEKPQTMASYS 1272
H+DC WVKRDSYLP GS LKA K KLGYDP+E++PEDM R A E+PQT+A+YS
Sbjct: 411 PQCIHMDCLRWVKRDSYLPVGSHNLKAAAKAKLGYDPVELDPEDMCRMATEQPQTLATYS 470
Query: 1273 VSDAVATYYLYMTYVHPFVFSLATIIPMVPDEVLRKGSGTLCEMLLMVEAYKANVVCPNK 1452
VSDAVATYYLYM YVHPF+F+L TIIPM PDEVLRKGSGTLCE LLMV+A+ AN++ PNK
Sbjct: 471 VSDAVATYYLYMKYVHPFIFALCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNK 530
Query: 1453 NQADPEKFYQ-GKLLESETYIGGHVECLQSGVFRSDIPTSFKLDASAYQQLIDNLGRDLE 1629
+ + K G +L+SETY+GGHVE L+SGVFRSDIP F+++ +A+ L+ + + L
Sbjct: 531 QEQEFNKLTDDGHVLDSETYVGGHVEALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTLR 590
Query: 1630 YAITVEGKMRMDSVSNFDEVKEVIREKLEKLRDDPIREEGPLIYHLDVAAMYPNIILTNR 1809
+A+ E K+ ++ V+NF+EV + I+ KL L+D P R E PLIYHLDV AMYPNIILTNR
Sbjct: 591 HALEEEEKVPVEQVTNFEEVCDEIKSKLASLKDVPSRIECPLIYHLDVGAMYPNIILTNR 650
Query: 1810 LQPPSIVTDEVCTACDFNGPEKTCLRKLEWVWRGVTFKGNKSEYYHLKKQIESESVDAGA 1989
LQP ++V + C ACDFN P C RK+ W WRG ++SEY+ ++ Q+ESE
Sbjct: 651 LQPSAMVDEATCAACDFNKPGANCQRKMAWQWRGEFMPASRSEYHRIQHQLESEKFPPLF 710
Query: 1990 NMQSSKPFLDLPKVEQQSKLKERLKKYCQKAYSRVLDKPITEVRE--AGICMRENPFYVD 2163
++ F +L + EQ K RL YC+KAY ++ IT+V E IC REN FYVD
Sbjct: 711 PEGPARAFHELSREEQAKYEKRRLADYCRKAYKKI---HITKVEERLTTICQRENSFYVD 767
Query: 2164 TVRSFRDRRYEYKTLNKVWKGKLSEAKASGNLIKIQEAHDMVVVYDSLQLAHKCILNSFY 2343
TVR+FRDRRYE+K L+KVWK KLS A G+ +++ +M V+YDSLQLAHKCILNSFY
Sbjct: 768 TVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDAAEVKRCKNMEVLYDSLQLAHKCILNSFY 827
Query: 2344 GYVMRKGARWYSMEMAGVVTYTGAKIIQNARLLIERIGKPLELDTDGIWCALPGSFPENF 2523
GYVMRKGARWYSMEMAG+V +TGA II AR LIE+IG+PLELDTDGIWC LP SFPENF
Sbjct: 828 GYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQIGRPLELDTDGIWCVLPNSFPENF 887
Query: 2524 TFKTIDMKK--FTISYPCVILNVDVAKNNSNDQYQTLVDPVRKTYNSRSECSIEFEVDGP 2697
FKT ++KK TISYP +LN+ V + +NDQYQ L +P TY +RSE SI FEVDGP
Sbjct: 888 VFKTTNVKKPKVTISYPGAMLNIMVKEGFTNDQYQELAEPSSLTYVTRSENSIFFEVDGP 947
Query: 2698 YKAMIIPASKEEGILIKKRYAVFNHDGTIAELKGFEMKRRGELKLIKVFQAELFDKFLHG 2877
Y AMI+PASKEEG +KKRYAVFN DG++AELKGFE+KRRGEL+LIK+FQ+ +F+ FL G
Sbjct: 948 YLAMILPASKEEGKKLKKRYAVFNEDGSLAELKGFEVKRRGELQLIKIFQSSVFEAFLKG 1007
Query: 2878 STLEECYSAVAAVANRWLDLLEGQGKDIADSELLDYISESSTMSKSLADYGQQKSCAVTT 3057
STLEE Y +VA VA+ WLD+L + ++ DSEL + ISE+ +MS+ L DYG+QKS +++T
Sbjct: 1008 STLEEVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKLEDYGEQKSTSIST 1067
Query: 3058 AKRLADFLGDTMVKDKGLRCQYIVAREPEGTPVSERAVPVAIFQTDDPEKKFYLQKWCKI 3237
AKRLA+FLGD MVKD GL C+YI++R+PEG+PV+ERA+P+AIFQ + +K +L+KW K
Sbjct: 1068 AKRLAEFLGDQMVKDAGLSCRYIISRKPEGSPVTERAIPLAIFQAEPTVRKHFLRKWLKS 1127
Query: 3238 SSYT--GIRSIIDWMYYKQRLHSAIQKVITIPAAMQKVANPVLRVRHPYWLEKKVCDK-- 3405
SS IR+I+DW YY +RL SAIQK+ITIPAA+Q+V NPV RV+HP WL KK+ +K
Sbjct: 1128 SSLQDFDIRAILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKHPDWLHKKLLEKND 1187
Query: 3406 -FRQGKIVDMFSSANKDHST----TQDN---VVADIEEFCKENRPSVKGPKPVARSFEVD 3561
++Q KI ++F+ + T ++D+ D+E+F P P V R +
Sbjct: 1188 VYKQKKISELFTLEGRRQVTMAEASEDSPRPSAPDMEDFGLVKLPHPAAPVTVKRKRVLW 1247
Query: 3562 RNHSEGKQQESWDPEFHDISLQNV---DKNVDYQGWLELEKRKWKM----TLTNKKKRRF 3720
+ E + P + +I Q ++ WL K+KW++ L +K++R
Sbjct: 1248 ESQEESQDLTPTVP-WQEILGQPPALGTSQEEWLVWLRFHKKKWQLQARQRLARRKRQRL 1306
Query: 3721 DDLKPCNQIDAHKINKKVCKGRVGVGSYFRRPEEALTSSYLQIIQLVQSPQSGQFFAWVV 3900
+ + + A + G+GS+ RR ++ QI+Q+ ++ Q+G F W +
Sbjct: 1307 ESAEGVLRPGAIRDGP-----ATGLGSFLRRTARSILDLPWQIVQISETSQAGLFRLWAL 1361
Query: 3901 VEGLMLKIPLTIPRVFYINSKASIAGNFTG-KCINKILPHGKPCYNLMEARHLHNTHILL 4077
V + I L+IPRVFY+N + + A + +N++LP YNL E
Sbjct: 1362 VGSDLHCIRLSIPRVFYVNQRVAKAEEGASYRKVNRVLPRSNMVYNLYE----------- 1410
Query: 4078 LVNIQEDQFIKESKKLAALLADPEIEGIYETKMPLEFSAICQIGCVCKI-EDTAKHRNTQ 4254
++ ED + + ++ A L+ P+IEG+YET++PL F A+ +GCVC + + +H +
Sbjct: 1411 -YSVPEDMYQEHINEINAELSAPDIEGVYETQVPLLFRALVHLGCVCVVNKQLVRHLS-- 1467
Query: 4255 DGWK-----LGELHRITTTECRYLE-NSIPLVYLYHSTSTGRAVYVLYCHASKLMSVVVV 4416
GW+ L L + + YLE SI +YLYH +A++ ++ + + SV V+
Sbjct: 1468 -GWEAETFALEHLEMRSLAQFSYLEPGSIRHIYLYHHAQAHKALFGIFIPSQRRASVFVL 1526
Query: 4417 NPYGDKEL--LSSALERQFRDRCQELSPEPFSWDGILFQVEYVDHPEAATKFLQKALCEY 4590
+ ++ L + + +++ PE F+V + + +Q+ L Y
Sbjct: 1527 DTVRTDQMPSLGALYSAEHGLLLEKVGPELLPPPKHTFEVRAETDLKTICRAIQRFLLAY 1586
Query: 4591 REENCGAT-VAVIECPDFNTTKEGVKALEDFPCVRIPFNDDDNSYQPVSWQRPAAKIAVL 4767
+EE G T +AV + + LE+FP V I D N Y + WQR A+ +
Sbjct: 1587 KEERRGPTLIAVQSSWELKRLASEIPVLEEFPLVPICVADKIN-YGVLDWQRHGARRMIR 1645
Query: 4768 RCASAIQWLDRRIAQSRYAHVPLGNFGRDWLTFTVDIFLSRALRDQQQVLWVSDNGVPDL 4947
+ L + SRY H+P+GN D TF D+F +R L+ +LW+S PDL
Sbjct: 1646 HYLNLDTCLSQAFEMSRYFHIPIGNLPEDISTFGSDLFFARHLQRHNHLLWLSPTARPDL 1705
Query: 4948 GDINNEETFLADELQETSLL---FPGAYRKVSVELKVHRLAVNALLKSDLVSEMEGGGFL 5118
G ++ L E + + + G Y V VEL + LAVN +L+S V++MEG +
Sbjct: 1706 GGKEADDNCLVMEFDDQATVEINSSGCYSTVCVELDLQNLAVNTILQSHHVNDMEGADSM 1765
Query: 5119 GVN-------------SRGSSLNDNGSFDENNGCAQAFRVLKQLIKRLLHDACNSGNIYA 5259
G++ + G + + S+DE C+ FR+LK ++ + + NIYA
Sbjct: 1766 GISFDVIQQASLEDMITGGQAASAPASYDETALCSNTFRILKSMVVGWVKEITQYHNIYA 1825
Query: 5260 DSILQHLSWWLRSPSSKLHDPALHLMLHKVMQKVFALLLTDLRRLGAIIIYADFSKVIID 5439
D+ + H WLRSPSS LHDPALH LH +M+K+F L+ + +RLG+ +IYA+F+++I+
Sbjct: 1826 DNQVMHFYRWLRSPSSLLHDPALHRTLHNMMKKLFLQLIAEFKRLGSSVIYANFNRIILC 1885
Query: 5440 TGKFDLSAAKTYCESLLTVMGSRDIFKLILLEPVHYWHSLLFMDQHNYAGIRATGD---- 5607
T K + A Y E + + + S++ F + + W LL+MD NY GI+
Sbjct: 1886 TKKRRVEDAIAYVEYITSSIHSKETFHSLTISFSRCWEFLLWMDPSNYGGIKGKVSSRIH 1945
Query: 5608 ---------------------------------EISGNEVTIEPKWSVARHLPE--YIQK 5682
E S E +E W++ + LP+ Q
Sbjct: 1946 CGLQDSQKAGGAEDEQENEDDEEERDGEEEEEAEESNVEDLLENNWNILQFLPQAASCQN 2005
Query: 5683 DFIIIVATFIF-------------GPWKFALEKKRGSAESLEAE--------MVEYLKEQ 5799
F++IV+ +I P + ++ S S EAE M+ + ++
Sbjct: 2006 YFLMIVSAYIVAVYHCMKDGLRRSAPGSTPVRRRGASQLSQEAEGAVGALPGMITFSQDY 2065
Query: 5800 IGTRFISMIVEKIGNIRSHIKDINVSDASWASGQAPKGDY------TFEFIQIITAVLAL 5961
+ I+ + S G + EFI+ + VL+L
Sbjct: 2066 VANELTQSFFTITQKIQKKVTGSRNSTELSEMFPVLPGSHLLLNNPALEFIKYVCKVLSL 2125
Query: 5962 DQNVQQDVLVMRKILLKYIKVKECAAEAEFIDPGPSFILPNVACSNCGAYRDLDFCRDSA 6141
D N+ V + + LL+ + V E + EA+F DP S++LP V C +C RDLD C+DS+
Sbjct: 2126 DTNITNQVNKLNRDLLRLVDVGEFSEEAQFRDPCRSYVLPEVICRSCNFCRDLDLCKDSS 2185
Query: 6142 LLTE----KEWSCADPQCVKIYDKEQIESSIIQMVRQRERMYQLQDLVCNRCNQVKAAHL 6309
+ +W C++ C YD IE +++++++++ + LQDLVC +C VK +
Sbjct: 2186 FSEDGAVLPQWLCSN--CQAPYDSSAIEMTLVEVLQKKLMAFTLQDLVCLKCRGVKETSM 2243
Query: 6310 TEQCECSGSFRCKESGSDFHKRIEIFLDIAKRQKFRLLEECISWIL 6447
C C+G F F ++I IF +IA+ L E + W+L
Sbjct: 2244 PVYCTCAGDFALTIHTQVFMEQIGIFRNIAQHYGMSYLLETLEWLL 2289
Database: BlastDB/NCBI/blast/db/2003_02_27_02_00_4/nr
Posted date: Feb 27, 2003 4:02 PM
Number of letters in database: 431,508,457
Number of sequences in database: 1,347,713
Lambda K H
0.318 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
length of database: 431,508,457
effective HSP length: 139
effective length of database: 244,176,350
effective search space used: 492015345250
frameshift window, decay const: 50, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)